Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | BRS3 | P32247 | 2/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690778 | 1.00 | MMP13 (0.48) | MMP13ALOX5KCNH2SCN3AFFAR4 | |
| SCHEMBL6693897 | 0.90 | MMP13 (0.43) | MMP13ALOX5KCNH2FFAR4MMP2 | |
| SCHEMBL6694975 | 0.82 | MMP2 (0.46) | MMP13KCNH2SCN3AMMP2MMP1 | |
| SCHEMBL7673139 | 0.81 | MMP13 (0.41) | MMP13ALOX5KCNH2MMP2MMP1 | |
| SCHEMBL6688866 | 0.81 | MMP1 (0.39) | MMP13KCNH2MMP2MMP1MMP3 | |
| SCHEMBL6693849 | 0.79 | S1PR5 (0.44) | MMP13FAAHMMP2MMP1MMP3 | |
| SCHEMBL6693902 | 0.78 | ACACB (0.34) | MMP13KCNH2SCN3AFAAHMMP2 | |
| SCHEMBL6693857 | 0.77 | MMP1 (0.48) | MMP13MMP2MMP1MMP3MMP9 | |
| SCHEMBL6692369 | 0.76 | S1PR5 (0.41) | MMP13KCNH2FFAR4MMP2MMP1 | |
| SCHEMBL6693917 | 0.66 | LIPG (0.36) | MMP13KCNH2FFAR4MMP2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | disclosed |