Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 4/20 | 0.57 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.57 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.57 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.57 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.57 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756245 | 0.90 | P2RY2 (0.64) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| Water SCHEMBL443839 | 0.89 | P2RY2 (0.63) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL3164897 | 0.86 | P2RY2 (0.65) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL4352328 | 0.85 | AHCY (0.61) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL27779375 | 0.85 | AHCY (0.61) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL8836085 | 0.84 | GK (0.64) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL28192648 | 0.84 | AHCY (0.60) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL6697169 | 0.84 | PI4KA (0.56) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL8835991 | 0.83 | AHCY (0.59) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 | |
| SCHEMBL8836012 | 0.83 | AHCY (0.59) | P2RY1P2RY2SRCSMN1; SMN2DNPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1469003-A2 | Tetraphosphonate bicyclic trisanhydrides | Pharmasset, Ltd. (US) | 2004-10-20 | — | — | EP | disclosed |
| US-20040181078-A1 | Tetraphosphonate bicyclic trisanhydrides | PHARMASSET, LTD. | 2004-09-16 | — | — | US | disclosed |
| US-6713623-B2 | USEFUL AS INTERMEDIATES IN THE SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS | PHARMASSET, LTD. | 2004-03-30 | — | — | US | disclosed |
| US-20020161220-A1 | Tetraphosphonate bicyclic trisanhydrides | GILEAD PHARMASSET LLC | 2002-10-31 | — | — | US | disclosed |
| US-6326490-B1 | ANTIPROLIFERATION AGENTS OR ANTICARCINOGENIC AGENTS | PHARMASSET, LTD. | 2001-12-04 | — | — | US | disclosed |
| EP-0934325-A4 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET LTD (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0934325-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | Pharmasset, Ltd. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015563-A1 | TETRAPHOSPHONATE BICYCLIC TRISANHYDRIDES | PHARMASSET, LTD. (US) | 1998-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181078-A1 | Tetraphosphonate bicyclic trisanhydrides | IDH1, PPIP5K2, DHPS | P2RY1 3076/4885P2RY2 3110/4885SRC 3192/4885 |
| US-20020161220-A1 | Tetraphosphonate bicyclic trisanhydrides | IDH1, PPIP5K2, DHPS | P2RY1 3076/4885P2RY2 3110/4885SRC 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.