Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29381263 | 1.00 | ADORA2A (0.44) | ADORA2AADORA1CCR8KMT2AAXL | |
| Trifluoroacetic Acid SCHEMBL29486292 | 0.86 | NOTUM (0.39) | ADORA2AADORA1JAK2TTBK1TTBK2 | |
| SCHEMBL14697441 | 0.73 | CCR8 (0.52) | ADORA2AADORA1CCR8KMT2AAXL | |
| SCHEMBL12613812 | 0.72 | PRKCI (0.43) | AXLPRKCIJAK2TTBK1TTBK2 | |
| SCHEMBL64925 | 0.71 | — | — | |
| SCHEMBL29407705 | 0.71 | — | — | |
| SCHEMBL2078432 | 0.71 | AXL (0.48) | AXLJAK2JAK3DYRK1ANUDT1 | |
| SCHEMBL1704740 | 0.71 | RPS6KA5 (0.37) | ADORA2ARPS6KA5 | |
| SCHEMBL7016693 | 0.71 | XDH (0.47) | ADORA2ARPS6KA5CCNT1CCNA2CDK2 | |
| SCHEMBL1566406 | 0.71 | AXL (0.53) | ADORA2AADORA1CCR8KMT2AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027119-A1 | INHIBITORS OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II AND THEIR USES | UNIV JOHNS HOPKINS (US) | 2026-01-29 | — | — | US | disclosed |
| WO-2024020092-A2 | INHIBITORS OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II AND THEIR USES | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| US-20230072683-A1 | PYRIDO-PYRIMIDIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION, FOR USE IN PREVENTING OR TREATING PI3 KINASE RELATED DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT | BORYUNG PHARMACEUTICAL CO., LTD. (KR) | 2023-03-09 | — | — | US | disclosed |
| US-8975250-B2 | 5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases | SANOFI (FR) | 2015-03-10 | — | — | US | disclosed |
| US-8975250-B2 | 5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases | SANOFI (FR) | 2015-03-10 | — | — | US | disclosed |
| US-8975250-B2 | 5 oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases | SANOFI (FR) | 2015-03-10 | — | — | US | disclosed |
| EP-2521726-B1 | 5-OXO-5,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASES INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2013-12-18 | — | — | EP | disclosed |
| CN-102791710-A | 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases | SANOFI AVENTIS | 2012-11-21 | — | — | CN | disclosed |
| CN-102791710-A | 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives as CaMKII kinase inhibitors for treating cardiovascular diseases | SANOFI AVENTIS | 2012-11-21 | — | — | CN | disclosed |
| EP-2521726-A1 | 5-OXO-5, 8-DIHYDROPYRIDO [2, 3-D]PYRIMIDINE DERIVATIVES AS CAMKII KINASE INHIBITORS FOR TREATING CARDIOVASCULAR DISEASES | SANOFI (FR) | 2012-11-14 | — | — | EP | disclosed |
| US-4526964-A | Intermediates useful in producing 5-deaza analogs of folic acid and aminopterin | SOUTHERN RESEARCH INSTITUTE (US) | 1985-07-02 | — | — | US | disclosed |
| US-4431805-A | ANTICARCINOGENIC AGENTS; LEUKEMIA; REDUCTASE INHIBITORS; FOLIC ACID ANTAGONISTS | SOUTHERN RESEARCH INSTITUTE (US) | 1984-02-14 | — | — | US | disclosed |
| EP-0075880-A2 | Pyrido (2,3-d) pyrimidines | Southern Research Institute (US) | 1983-04-06 | — | — | EP | disclosed |
| US-RE30024-E | ANTIALLERGENS | STERLING DRUG INC. (US) | 1979-06-05 | — | — | US | disclosed |
| US-4118571-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4103011-A | BACTERICIDES | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1978-07-25 | — | — | US | disclosed |
| US-4086233-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4032523-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
| US-4018770-A | ANTIALLERGENS | STERLING DRUG INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-3992380-A | 5,8-Dihydro-5-oxo-2-(4-or 3-pyridinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acids and esters | STERLING DRUG INC. (US) | 1976-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260027119-A1 | INHIBITORS OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II AND THEIR USES | CAMKK1, CAMK2B, CAMKK2 | ADORA2A 892/4885ADORA1 1072/4885CCR8 4721/4885 |
| US-20230072683-A1 | PYRIDO-PYRIMIDIN DERIVATIVES AND PHARMACEUTICAL COMPOSITION, FOR USE IN PREVENTING OR TREATING PI3 KINASE RELATED DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT | PIK3CA, PDXK, PIK3CD | ADORA2A 1200/4885ADORA1 775/4885CCR8 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.