Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | LIPE | Q05469 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728948 | 0.86 | SLC2A1 (0.59) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL29721165 | 0.86 | SLC2A1 (0.59) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL11163647 | 0.86 | LMNA (0.55) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL2096058 | 0.85 | LMNA (0.61) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL11857933 | 0.85 | CYP19A1 (0.57) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL15787241 | 0.84 | MAOB (0.54) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL16981016 | 0.84 | TTR (0.51) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL17685895 | 0.84 | APP (0.65) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL2775028 | 0.84 | MAOB (0.52) | LMNAAPPMCL1MAOBLIPE | |
| SCHEMBL3418336 | 0.84 | PTGES (0.55) | LMNAAPPMCL1MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117645594-A | Preparation method of oroxylin A | 南京杰运医药科技有限公司 | 2024-03-05 | — | — | CN | disclosed |
| US-20040049056-A1 | Process for preparation of esculetin compounds, esculetin compounds and intermediates thereof, and use of both | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1357118-A1 | PROCESS FOR PREPARATION OF ESCULETIN COMPOUNDS, ESCULETIN COMPOUNDS AND INTERMEDIATES THEREOF, AND USE OF BOTH | Kureha Chemical Industry Co., Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-4664929-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1987-05-12 | — | — | US | disclosed |
| US-4633006-A | ARTIFICIAL SWEETENERS | GENERAL FOODS CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |
| US-4626442-A | 3-hydroxy-4-alkyloxyphenyl heterocyclic aromatic carboxylates | GENERAL FOODS CORPORATION (US) | 1986-12-02 | — | — | US | disclosed |
| US-4602095-A | 3-hydroxy-4-alkyloxyphenyl heterocyclic aromatic carboxylates | GENERAL FOODS CORPORATION (US) | 1986-07-22 | — | — | US | disclosed |
| US-4546000-A | 3-Hydroxy-4-alkyloxyphenyl aliphatic carbonates | GENERAL FOODS CORPORATION (US) | 1985-10-08 | — | — | US | disclosed |
| US-4545999-A | 3-Hydroxy-4-methoxyphenyl aryl carbonates | GENERAL FOODS CORPORATION (US) | 1985-10-08 | — | — | US | disclosed |
| US-4544566-A | 3-Hydroxy-4-alkyloxyphenyl heterocyclic carbonates | GENERAL FOODS CORPORATION (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0146913-A2 | 3-hydroxy-4-alkyloxyphenyl heterocyclic aromatic carboxylates, foodstuffs containing said compounds as sweetening agents and process for modifying the sweetness perception in a foodstuff | GENERAL FOODS CORPORATION (US) | 1985-07-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040049056-A1 | Process for preparation of esculetin compounds, esculetin compounds and intermediates thereof, and use of both | SUCLG1, SALL4, HSD17B14 | LMNA 2746/4885CYP1A2 96/4885PTGS1 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.