Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6703548 | 0.87 | NPC1 (0.46) | MAOAMAOBNPC1RAB9AMEN1 | |
| SCHEMBL6704193 | 0.85 | NPC1 (0.47) | MAOAMAOBNPC1RAB9AMEN1 | |
| SCHEMBL6703029 | 0.81 | MAOA (0.39) | MAOAMAOBNPC1RAB9AMEN1 | |
| SCHEMBL6703223 | 0.80 | ALDH1A1 (0.40) | MAOAMAOBNPC1RAB9AANO1 | |
| SCHEMBL7090856 | 0.79 | MAOA (0.38) | MAOAMAOBNPC1SLC6A2SLC6A4 | |
| SCHEMBL6703053 | 0.77 | PGR (0.43) | MAOAMAOBANO1 | |
| SCHEMBL8110867 | 0.72 | MAOA (0.67) | MAOAMAOBNPC1RAB9AMEN1 | |
| SCHEMBL6705267 | 0.70 | MAPT (0.40) | MAOAMAOBNPC1RAB9AMEN1 | |
| SCHEMBL7759631 | 0.70 | NPC1 (0.55) | NPC1RAB9AMEN1KMT2AHDAC2 | |
| SCHEMBL12867819 | 0.67 | MAOA (0.44) | MAOAMAOBNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102488-A1 | Butenolide and pentenolide derivatives as kinase inhibitors | MORPHOCHEM AG (DE) | 2004-05-27 | — | — | US | disclosed |
| EP-1324984-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | Morphochem AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030892-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | MORPHOCHEM AG (DE) | 2002-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102488-A1 | Butenolide and pentenolide derivatives as kinase inhibitors | MAP3K20, MAP3K21, MAP3K1 | MAOA 3783/4885MAOB 3533/4885NPC1 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.