Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989070 | 0.88 | LMNA (0.43) | MAOAMAOBALDH1A1HPGDNPC1 | |
| SCHEMBL6987318 | 0.82 | CYP3A4 (0.35) | MAOAMAOBALDH1A1HPGDLMNA | |
| SCHEMBL6987344 | 0.81 | MAPT (0.34) | ALDH1A1CYP1A2NPC1LMNAMAPT | |
| SCHEMBL6700660 | 0.79 | MAOA (0.46) | MAOAMAOBSLC6A2SLC6A3SLC6A4 | |
| SCHEMBL6988241 | 0.78 | PGR (0.41) | — | |
| SCHEMBL6703548 | 0.65 | NPC1 (0.46) | MAOAMAOBALDH1A1NPC1LMNA | |
| SCHEMBL27894590 | 0.65 | SCN9A (0.47) | ALDH1A1NPC1LMNAMAPTCASP3 | |
| SCHEMBL1893211 | 0.65 | ALDH1A1 (0.51) | ALDH1A1CYP1A2NPC1LMNAMAPT | |
| SCHEMBL27747046 | 0.65 | NCEH1 (0.40) | MAOAMAOBALDH1A1HPGDHSD17B10 | |
| SCHEMBL5486246 | 0.64 | NPC1 (0.45) | CYP1A2NPC1LMNAMAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324984-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | Morphochem AG (DE) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030892-A1 | BUTENOLIDE AND PENTENOLIDE DERIVATIVES AS KINASE INHIBITORS | MORPHOCHEM AG (DE) | 2002-04-18 | — | — | WO | disclosed |