Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.71 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.71 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | APP | P05067 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | RECQL | P46063 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1058712 | 0.85 | HPGD (0.78) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL30143812 | 0.85 | HPGD (0.78) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL312255 | 0.83 | AKR1C3 (1.00) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL5130604 | 0.83 | AKR1C3 (0.71) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL5126242 | 0.77 | AKR1C3 (0.61) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL11561745 | 0.77 | AKR1C3 (0.61) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL131759 | 0.77 | MEN1 (1.00) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL10144252 | 0.77 | APP (1.00) | MEN1KMT2AHPGDTP53APP | |
| SCHEMBL29373668 | 0.77 | MEN1 (1.00) | AKR1C3AKR1C2AKR1C1MEN1KMT2A | |
| SCHEMBL718119 | 0.74 | HPGD (0.74) | AKR1C3AKR1C2AKR1C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147597-A1 | Anti-mycobacterium compositions and methods of preparing and using same | ADVANCED LIFE SCIENCES, INC. | 2004-07-29 | — | — | US | disclosed |
| US-6677350-B1 | ADMINISTERING CHALCONE-LIKE VINYLCARBONYL COMPOUNDS TO PREVENT OR TREAT MYCOBACTERIUM INFECTIONS/TUBERCULOSIS | ADVANCED LIFE SCIENCES, INC. | 2004-01-13 | — | — | US | disclosed |
| EP-1217995-A2 | ANTI-MYCOBACTERIUM COMPOSITIONS AND METHODS OF PREPARING AND USING SAME | Advanced Life Sciences Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021164-A2 | ANTI-MYCOBACTERIUM COMPOSITIONS AND METHODS OF PREPARING AND USING SAME | ADVANCED LIFE SCIENCES, INC. (US) | 2001-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147597-A1 | Anti-mycobacterium compositions and methods of preparing and using same | IMMT, CYP51A1, LSS | AKR1C3 816/4885AKR1C2 1177/4885AKR1C1 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.