SCHEMBL6701382

SCHEMBL6701382

CC(Oc1ccc(CC(OCc2ccc(F)cc2)C(=O)O)cc1)c1nc2ccc(Sc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)cc2[nH]1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 9/20 0.35
PPARG P37231 8/20 0.35
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
S1PR1 P21453 5/20 0.34
PPARD Q03181 4/20 0.33
PTPN1 P18031 2/20 0.32
S1PR4 O95977 4/20 0.32
TUBB4A P04350 1/20 0.31
TUBB P07437 1/20 0.31
MET P08581 1/20 0.31
TUBA3C P0DPH7 1/20 0.31
TUBA1B P68363 1/20 0.31
TUBA4A P68366 1/20 0.31
TUBB4B P68371 1/20 0.31
TUBB3 Q13509 1/20 0.31
TUBB2A Q13885 1/20 0.31
TUBB8 Q3ZCM7 1/20 0.31
TUBA3E Q6PEY2 1/20 0.31
TUBA1A Q71U36 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6703614 0.93 MAOA (0.33) MAOAMAOBS1PR1TUBB4ATUBB
SCHEMBL6697827 0.86 ALDH1A1 (0.35) S1PR1S1PR4S1PR5MEN1NR1I2
SCHEMBL6699623 0.81 CYP1A2 (0.35) S1PR1S1PR4MEN1NR1I2LMNA
Hydrochloric Acid SCHEMBL6700552 0.81 MEN1 (0.35) S1PR1S1PR4MEN1NR1I2LMNA
SCHEMBL6697832 0.79 SCN10A (0.38) MEN1NR1I2LMNACYP1A2KMT2A
SCHEMBL6701377 0.78 ESRRA (0.44) PPARAPPARG
SCHEMBL6544826 0.77 MEN1 (0.34) MEN1NR1I2LMNACYP1A2KMT2A
SCHEMBL6699629 0.76 SCN10A (0.37) MEN1NR1I2LMNACYP1A2KMT2A
SCHEMBL6543663 0.75 PPARG (0.43) PPARAPPARG
Hydrochloric Acid SCHEMBL6700556 0.75 SCN10A (0.36) MEN1NR1I2LMNACYP1A2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040002512-A1 Alpha-substituted carboxylic acid derivatives SANKYO COMPANY, LIMITED (JP) 2004-01-01 US claimed
US-20030069294-A1 Alpha-substituted carboxylic acid derivatives SANKYO COMPANY, LIMITED (JP) 2003-04-10 US claimed
EP-1167357-A1 ALPHA-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES Sankyo Company, Limited (JP) 2002-01-02 EP claimed
US-20040002512-A1 Alpha-substituted carboxylic acid derivatives SANKYO COMPANY, LIMITED (JP) 2004-01-01 US disclosed
US-6596751-B2 An insulin resistance improving agent, hypoglycemic agent, immunoregulatory agent, aldose reductase inhibitor, 5-lipoxygenase inhibitor, peroxidized lipid production suppressor, PPAR. activator, leukotriene antagonist, adipose SANKYO COMPANY LIMITED (JP) 2003-07-22 US disclosed
US-20030069294-A1 Alpha-substituted carboxylic acid derivatives SANKYO COMPANY, LIMITED (JP) 2003-04-10 US disclosed
EP-1167357-A1 ALPHA-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES Sankyo Company, Limited (JP) 2002-01-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040002512-A1 Alpha-substituted carboxylic acid derivatives SLC5A1, SLC2A1, GPR119 PPARA 216/4885PPARG 152/4885MAOA 2021/4885
US-20030069294-A1 Alpha-substituted carboxylic acid derivatives SLC5A1, SLC2A1, GPR119 PPARA 216/4885PPARG 152/4885MAOA 2021/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.