SCHEMBL6701534

SCHEMBL6701534

O=C(c1ccc(-n2ncc(=O)[nH]c2=O)cc1)c1cc(Cl)c(Cl)c(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 10/20 0.47
ABCB11 O95342 1/20 0.45
MEN1 O00255 1/20 0.44
NR1I2 O75469 1/20 0.44
KMT2A Q03164 1/20 0.44
THRB P10828 9/20 0.40
THRA P10827 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6479192 0.87 KMT2A (0.50) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL5566665 0.80 MEN1 (0.58) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL5561613 0.79 MEN1 (0.52) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL7909905 0.76 KMT2A (0.58) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL7472949 0.76 MEN1 (0.51) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL7917755 0.75 MEN1 (0.53) P2RX7MEN1NR1I2KMT2ATHRB
SCHEMBL1412972 0.74 P2RX7 (0.65) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL1412866 0.74 P2RX7 (0.64) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL10512600 0.73 HIF1A (0.50) P2RX7ABCB11MEN1NR1I2KMT2A
SCHEMBL6701530 0.72 MEN1 (0.45) P2RX7ABCB11MEN1NR1I2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs LACRAMPE JEAN FERNAND ARMAND (FR) 2004-08-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs IL6ST, CXCR5, ALOX5 P2RX7 316/4885ABCB11 3042/4885MEN1 4239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.