SCHEMBL6702374

SCHEMBL6702374

CC1(C)N=C(c2ccccc2-c2ccccc2C2=NC(C)(C)C(=O)O2)OC1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 5/20 0.34
KDM4E B2RXH2 3/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
MAPK1 P28482 3/20 0.34
NPSR1 Q6W5P4 3/20 0.34
APAF1 O14727 2/20 0.34
TDP2 O95551 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
CES2 O00748 1/20 0.34
TERT O14746 1/20 0.34
PLIN1 O60240 1/20 0.34
S1PR4 O95977 1/20 0.34
LMNA P02545 1/20 0.34
PLA2G1B P04054 1/20 0.34
BCHE P06276 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10583841 0.98 ALOX15 (0.39) ALOX15TDP1MAPTKDM4EMEN1
SCHEMBL6468308 0.82 KDM4E (0.33) ALOX15TDP1KDM4EMEN1KMT2A
SCHEMBL3384398 0.81 ALDH1A1 (0.46) TDP1MAPTKDM4EMEN1KMT2A
Hydrochloric Acid SCHEMBL11729437 0.79 ALDH1A1 (0.45) TDP1MAPTKDM4EMEN1KMT2A
SCHEMBL24241764 0.78 MAPT (0.44) MAPTMEN1KMT2AMAPK1NPSR1
SCHEMBL6698057 0.76 ALDH1A1 (0.36) MAPTKDM4EMEN1KMT2AMAPK1
SCHEMBL15993777 0.73 CA1 (0.35) MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL24534547 0.73 ALDH1A1 (0.47) MAPTKDM4EMEN1KMT2AMAPK1
SCHEMBL2317085 0.70 ALDH1A1 (0.36) ALOX15TDP1MAPTMEN1KMT2A
SCHEMBL24241601 0.70 ALDH1A1 (0.36) MAPTKDM4EMEN1KMT2AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040068059-A1 Aliphatic polyester copolymer and process for producing the same, biodegradable resin molding based on aliphatic polyester, and lactone-containing resin DAICEL CHEMICAL INDUSTRIES LTD. (JP) 2004-04-08 US disclosed
EP-1354908-A1 ALIPHATIC POLYESTER COPOLYMER AND PROCESS FOR PRODUCING THE SAME, BIODEGRADABLE RESIN MOLDING BASED ON ALIPHATIC POLYESTER, AND LACTONE-CONTAINING RESIN DAICEL CHEMICAL INDUSTRIES, Ltd. (JP) 2003-10-22 EP disclosed
EP-0710684-B1 Preparation process of polyhydroxycarboxylic acid MITSUI CHEMICALS INC (JP) 2001-01-31 EP disclosed
EP-0710684-A2 Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-08 EP disclosed
US-5139885-A Aroamtic polester, halogenated diol, diglycidyl or dicarboxylic acid and a-di-heterocyclic compound; flexible heat stable POLYPLASTICS CO., LTD. (JP) 1992-08-18 US disclosed
US-5079284-A Halogenated nitrogen heterocycle as flame retardant POLYPLASTICS CO., LTD. (JP) 1992-01-07 US disclosed
US-4954541-A POLYESTER, HALOGENATED COMPOUND, HETEROCYCLIC COMPOUND POLYPLASTICS CO., LTD. (JP) 1990-09-04 US disclosed
EP-0320159-A1 Flame-retardant resin composition and electric wire POLYPLASTICS CO. LTD. (JP) 1989-06-14 EP disclosed
EP-0019061-B1 PROCESS FOR PRODUCING AROMATIC POLYESTERS HAVING INCREASED DEGREES OF POLYMERIZATION AND MOULDED ARTICLES COMPOSED OF THESE POLYESTERS TEIJIN LIMITED (JP) 1984-08-08 EP disclosed
US-4291152-A CHAIN EXTENSION WITH BICYCLIC OXAZINONE OR OXAZOLONE TEIJIN LIMITED (JP) 1981-09-22 US disclosed
EP-0019061-A1 Process for producing aromatic polyesters having increased degrees of polymerization and moulded articles composed of these polyesters TEIJIN LIMITED (JP) 1980-11-26 EP disclosed