Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HK2 | P52789 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11729437 | 0.98 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL24241764 | 0.96 | MAPT (0.44) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6136012 | 0.90 | ALDH1A1 (0.36) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6698057 | 0.87 | ALDH1A1 (0.36) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL10583841 | 0.82 | ALOX15 (0.39) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL24241601 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL2317085 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL6702374 | 0.81 | ALOX15 (0.38) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL24534547 | 0.80 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL24534438 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MAPTHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552206-B2 | NF-κB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-10-08 | — | — | US | disclosed |
| US-7858808-B2 | Multi-substituted imidazolines and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-12-28 | — | — | US | disclosed |
| US-20100204260-A1 | Multi-Substituted Imidazolines And Method Of Use Thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2010-08-12 | — | — | US | disclosed |
| US-7652056-B2 | Using 4-imidazoline carboxylic acid or ester; antiinflammatory agents; microbiocides; bactericides; antitumor agenst0 | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2010-01-26 | — | — | US | disclosed |
| US-20090275603-A1 | NF- kB Inhibitors And Uses Thereof | MICHIGAN STATE UNIVERSITY | 2009-11-05 | — | — | US | disclosed |
| WO-2009127722-A1 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |
| WO-2009127722-A1 | NOVEL MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-10-22 | — | — | WO | disclosed |
| EP-1534686-B1 | NF-KB INHIBITORS AND USES THEREOF | UNIV MICHIGAN STATE (US) | 2009-05-20 | — | — | EP | disclosed |
| US-7528161-B2 | NF-kappaB inhibitors and uses thereof | MICHIGAN STATE UNIVERSITY (US) | 2009-05-05 | — | — | US | disclosed |
| EP-2034994-A2 | NF-KAPPA B INHIBITORS AND USES THEREOF | The Board Of Trustees Operating Michigan State University (US) | 2009-03-18 | — | — | EP | disclosed |
| EP-1534686-A2 | NF-KB INHIBITORS AND USES THEREOF | Michigan State University (US) | 2005-06-01 | — | — | EP | disclosed |
| US-6878735-B2 | Multi-substituted imidazolines and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-04-12 | — | — | US | disclosed |
| US-20050020586-A1 | NF-kappaB inhibitors and uses thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2005-01-27 | — | — | US | disclosed |
| WO-2004066996-A1 | NF-kB INHIBITORS AND USES THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2004-08-12 | — | — | WO | disclosed |
| US-20030232870-A1 | Multi-substituted imidazolines and method of use thereof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-12-18 | — | — | US | disclosed |
| US-20030232998-A1 | NF-kB inhibitors and uses threreof | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2003-12-18 | — | — | US | disclosed |
| WO-2003101954-A2 | NF-KB INHIBITORS AND USES THEREOF | MICHIGAN STATE UNIVERSITY (US) | 2003-12-11 | — | — | WO | disclosed |
| EP-0480568-B1 | Post-processing stabilization of photothermographic emulsions | MINNESOTA MINING & MFG (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5175081-A | Post-processsing stabilization of photothermographic emulsions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0480568-A2 | Post-processing stabilization of photothermographic emulsions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-04-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275603-A1 | NF- kB Inhibitors And Uses Thereof | NFKBIA, IKBKB, IKBKG | ALDH1A1 4090/4885MAPT 4269/4885HPGD 2950/4885 |
| US-20030232998-A1 | NF-kB inhibitors and uses threreof | NFKBIA, IKBKB, IKBKG | ALDH1A1 4588/4885MAPT 3437/4885HPGD 4284/4885 |
| US-20050020586-A1 | NF-kappaB inhibitors and uses thereof | NFKBIA, IKBKB, IKBKG | ALDH1A1 3788/4885MAPT 4502/4885HPGD 2758/4885 |
| US-20030232870-A1 | Multi-substituted imidazolines and method of use thereof | IKBKB, NFKBIA, IKBKG | ALDH1A1 4715/4885MAPT 4506/4885HPGD 3089/4885 |
| US-20100204260-A1 | Multi-Substituted Imidazolines And Method Of Use Thereof | NFKBIA, IKBKB, CHUK | ALDH1A1 4640/4885MAPT 4624/4885HPGD 2357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.