Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | EIF4EBP1 | Q13541 | 4/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6697480 | 0.90 | PARP10 (0.45) | PARP10EIF4EBP1MCL1GAAMEN1 | |
| SCHEMBL6702695 | 0.87 | MEN1 (0.48) | EIF4EBP1MCL1GAAMEN1ALDH1A1 | |
| SCHEMBL6703389 | 0.84 | MCHR1 (0.43) | GAAMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL6703820 | 0.79 | MAPK1 (0.56) | MCL1GAAMEN1ALDH1A1CYP2C9 | |
| SCHEMBL2118644 | 0.77 | HDAC6 (0.46) | MCL1GAAMEN1ALDH1A1CYP2C9 | |
| SCHEMBL6697485 | 0.74 | KCNA5 (0.48) | MEN1ALDH1A1HPGDKMT2ASMN1; SMN2 | |
| SCHEMBL2117041 | 0.73 | HDAC6 (0.44) | MCL1 | |
| SCHEMBL6192789 | 0.73 | RHEB (0.44) | MCL1PKMPLA2G4AITGB3ITGA2B | |
| SCHEMBL1609166 | 0.73 | MCL1 (0.63) | MCL1MAPK1POLBCASP6PKM | |
| SCHEMBL6180717 | 0.72 | MAPK1 (0.48) | EIF4EBP1MCL1GAAMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044000-A1 | Isoquinoline derivatives as matrix metalloproteinase inhibitors | MMP1, MMP13, MMP9 | PARP10 430/4885EIF4EBP1 3688/4885MCL1 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.