Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | CLPP | Q16740 | 1/20 | 0.33 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | PARG | Q86W56 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6704891 | 0.93 | MMP13 (0.42) | NPSR1MMP13SLC22A8CLPPALDH1A1 | |
| SCHEMBL6818788 | 0.81 | NPSR1 (0.38) | NPSR1MMP13SLC22A8CLPPALDH1A1 | |
| SCHEMBL6705127 | 0.76 | PTGS1 (0.38) | MMP13SLC22A8ALDH1A1HTTPKM | |
| SCHEMBL6699411 | 0.74 | NPSR1 (0.38) | NPSR1MMP13SLC22A8PCSK9ALDH1A1 | |
| SCHEMBL6390853 | 0.74 | MMP13 (0.62) | NPSR1MMP13SLC22A8TP53PARG | |
| SCHEMBL6700993 | 0.74 | MAPT (0.38) | NPSR1PCSK9ALDH1A1HTTTP53 | |
| SCHEMBL6702588 | 0.73 | MMP13 (0.39) | NPSR1MMP13SLC22A8PCSK9ALDH1A1 | |
| SCHEMBL6704876 | 0.73 | MMP13 (0.39) | NPSR1MMP13SLC22A8ALDH1A1TP53 | |
| SCHEMBL6703241 | 0.72 | TP53 (0.42) | NPSR1PCSK9ALDH1A1HTTTP53 | |
| SCHEMBL6703297 | 0.68 | MMP13 (0.42) | NPSR1MMP13SLC22A8ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040038994-A1 | Pyrimidine fused bicyclic metalloproteinase inhibitors | WILSON MICHAEL WILLIAM (US) | 2004-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038994-A1 | Pyrimidine fused bicyclic metalloproteinase inhibitors | MMP9, MMP1, MMP2 | NPSR1 3417/4885MMP13 13/4885SLC22A8 2959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.