Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.52 |
| ▸ | CCR5 | P51681 | 10/20 | 0.52 |
| ▸ | MTR | Q99707 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3639939 | 0.85 | KCNA3 (0.65) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL12652353 | 0.85 | BACE1 (0.45) | KCNA3SIGMAR1BACE1 | |
| SCHEMBL7239884 | 0.84 | CARM1 (0.64) | KCNA3CYP2D6CCR5BACE1 | |
| Hydrochloric Acid SCHEMBL6698846 | 0.84 | KCNA3 (0.63) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL6705454 | 0.83 | KCNA3 (0.67) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL6702854 | 0.83 | KCNA3 (0.62) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL6700399 | 0.83 | KCNA3 (0.58) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL6701415 | 0.82 | KCNA3 (0.57) | KCNA3SIGMAR1CYP2D6OPRM1OPRL1 | |
| SCHEMBL1807864 | 0.79 | DRD2 (0.53) | KCNA3SIGMAR1BACE1 | |
| SCHEMBL12652357 | 0.79 | ALDH1A1 (0.54) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2004-01-08 | — | — | US | disclosed |
| EP-1289957-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087839-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | CCR5, CCR2, CCR1 | KCNA3 2564/4885SIGMAR1 450/4885CYP2D6 1355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.