Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5864026 | 0.81 | KEAP1 (0.39) | NR1H2NR1H3KEAP1NFE2L2HCRTR1 | |
| SCHEMBL5863634 | 0.78 | NR1H2 (0.38) | NR1H2NR1H3HSP90AA1HSP90AB1KEAP1 | |
| SCHEMBL5864051 | 0.77 | ABL1 (0.40) | NR1H2NR1H3HSP90AA1HSP90AB1 | |
| SCHEMBL6705581 | 0.75 | GLA (0.39) | NR1H2NR1H3KEAP1NFE2L2GLA | |
| SCHEMBL5863647 | 0.74 | RAPGEF4 (0.39) | NR1H2NR1H3HSP90AA1HSP90AB1KEAP1 | |
| SCHEMBL5864216 | 0.73 | SIGMAR1 (0.40) | NR1H2NR1H3KEAP1NFE2L2MEN1 | |
| SCHEMBL5864868 | 0.73 | SIGMAR1 (0.38) | GAA | |
| SCHEMBL5864171 | 0.73 | HRH3 (0.37) | — | |
| SCHEMBL6705574 | 0.72 | MAPT (0.38) | KEAP1NFE2L2GLAMAPTL3MBTL1 | |
| SCHEMBL5863949 | 0.72 | KEAP1 (0.40) | NR1H2NR1H3HSP90AA1HSP90AB1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | PFIZER INC | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110767-A1 | Acyclic amide and sulfonamide ligands for the estrogen receptor | GHSR, GPER1, SSTR1 | SLC40A1 3752/4885NR1H2 196/4885NR1H3 294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.