Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FOS | P01100 | 1/20 | 0.46 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16109076 | 0.82 | MAPT (0.56) | MAPTLMNAALDH1A1TSHRTHRB | |
| SCHEMBL27911613 | 0.82 | FOS (0.61) | MAPTLMNAALDH1A1TSHRTHRB | |
| SCHEMBL10640302 | 0.81 | MAPT (0.53) | MAPTLMNAALDH1A1TSHRTHRB | |
| SCHEMBL13762874 | 0.81 | MAPT (0.53) | MAPTLMNAALDH1A1TSHRTHRB | |
| SCHEMBL11739719 | 0.81 | NR1H4 (0.55) | GSK3BMAPTALDH1A1TSHRNR1H4 | |
| SCHEMBL3010302 | 0.80 | MAPT (0.73) | MAPTLMNAALDH1A1NR1H4POLB | |
| SCHEMBL1461812 | 0.80 | NPC1 (0.68) | GSK3BMAPTLMNAALDH1A1TSHR | |
| SCHEMBL834902 | 0.80 | NR1H4 (0.70) | MAPTLMNATSHRNR1H4POLB | |
| SCHEMBL25139483 | 0.79 | MAPT (0.53) | MAPTLMNAALDH1A1TSHRTHRB | |
| SCHEMBL17341985 | 0.79 | PARP10 (0.65) | MAPTLMNAALDH1A1NR1H4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040142942-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | ZHU YUN-FEI (US) | 2004-07-22 | — | — | US | disclosed |
| US-20020077327-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2002-06-20 | — | — | US | disclosed |
| EP-1185530-A1 | IMIDAZO- AND PYRROLO[1,2-A]PYRIMID-4-ONES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | Neurocrine Biosciences, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000069859-A1 | IMIDAZO- AND PYRROLO[1,2-A]PYRIMID-4-ONES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2000-11-23 | — | — | WO | disclosed |
| US-4033978-A | Thiacycl[2.2.2]azine carboxylic acids | SYNTEX (U.S.A.) INC. (US) | 1977-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142942-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | GSK3B 2672/4885MAPT 4654/4885LMNA 4003/4885 |
| US-20020077327-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | GSK3B 2672/4885MAPT 4654/4885LMNA 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.