Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.72 |
| ▸ | LMNA | P02545 | 6/20 | 0.72 |
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30487282 | 1.00 | SMN1; SMN2 (0.72) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL27728902 | 0.86 | ALDH1A1 (0.77) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL8758346 | 0.85 | ALDH1A1 (0.82) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL18499262 | 0.85 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL15503856 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL7421449 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL30487286 | 0.82 | ALDH1A1 (1.00) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL28527982 | 0.82 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL6802019 | 0.82 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL28467331 | 0.82 | ALDH1A1 (0.70) | SMN1; SMN2ALDH1A1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108047226-B | Matrine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108358923-B | Sophoridine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108358923-A | Sophoridine pyrroles, indole derivatives and the preparation method and application thereof | 广西大学 | 2018-08-03 | — | — | CN | claimed |
| CN-116535386-A | Cyanoethylene sulfonyl anilide compound and preparation method and medical application thereof | 西南大学 | 2023-08-04 | — | — | CN | disclosed |
| US-20040067998-A1 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition | YANG JI CHEMICAL COMPANY LTD (KR) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067998-A1 | Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition | IDO1, IDO2, TPH1 | SMN1; SMN2 4643/4885ALDH1A1 3031/4885LMNA 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.