Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | GALR3 | O60755 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL8816122 | 0.97 | CYP3A4 (0.65) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL8816125 | 0.97 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL119824 | 0.89 | LMNA (0.67) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL6706932 | 0.87 | MEN1 (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL540807 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686208 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL10630113 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1686210 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL2222247 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316506 | 0.86 | LMNA (0.63) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577583-A1 | Process for preparing granular esters | Akzo Nobel N.V. (NL) | 1994-01-05 | — | — | EP | claimed |
| CN-118290484-A | Amphiphilic platinum-based complex and preparation method and application thereof | 中国药科大学 | 2024-07-05 | — | — | CN | disclosed |
| US-10570161-B2 | Unique dual-action therapeutics | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2020-02-25 | — | — | US | disclosed |
| US-20170143836-A1 | UNIQUE DUAL-ACTION THERAPEUTICS | LEHIGH UNIVERSITY | 2017-05-25 | — | — | US | disclosed |
| WO-2010051044-A1 | UNIQUE DUAL-ACTION THERAPEUTICS | UNIVERSITY OF MEDICINE AND DENTISTRY (US) | 2010-05-06 | — | — | WO | disclosed |
| EP-1599471-B1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | EP | disclosed |
| US-7192974-B2 | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |
| US-20060270637-A1 | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | US | disclosed |
| EP-1599471-A1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | Astrazeneca AB (SE) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004078753-A1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |
| WO-1997024157-A9 | MOLECULES FOR IONTOPHORETIC DELIVERY | — | 1997-09-25 | — | — | WO | disclosed |
| WO-1997024157-A1 | MOLECULES FOR IONTOPHORETIC DELIVERY | BECTON, DICKINSON AND COMPANY (US) | 1997-07-10 | — | — | WO | disclosed |
| US-5494679-A | Molecules for iontophoretic delivery | BECTON DICKINSON AND COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0284132-B1 | Quaternary ammonium or phosphonium peroxy carbonic acid precursors and their use in detergent bleach compositions | UNILEVER NV (NL) | 1994-01-12 | — | — | EP | disclosed |
| EP-0552878-A2 | Molecules for iontophoretic delivery | Becton, Dickinson and Company (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0490417-A1 | Bleach-builder precursors | UNILEVER N.V. (NL) | 1992-06-17 | — | — | EP | disclosed |
| US-5069812-A | DERIVATIVES OF 2,6-DICARBOXY-4-OXY-PYRIDINES | LEVER BROTHERS COMPANY (US) | 1991-12-03 | — | — | US | disclosed |
| US-4818426-A | COLOR SAFE, USABLE IN COLD WATER | LEVER BROTHERS COMPANY (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0284132-A2 | Quaternary ammonium or phosphonium peroxy carbonic acid precursors and their use in detergent bleach compositions | UNILEVER N.V. (NL) | 1988-09-28 | — | — | EP | disclosed |
| US-4751015-A | LOW TEMPERATURE BLEACH | LEVER BROTHERS COMPANY (US) | 1988-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143836-A1 | UNIQUE DUAL-ACTION THERAPEUTICS | ACHE, PDE1A, PDE1C | LMNA 1179/4885MEN1 4406/4885KMT2A 3403/4885 |
| US-20060270637-A1 | Hydroxymethyl substituted dihydroisoxazole derivatives useful as antibiotic agents | RPS7, CYP3A7, CYP2A7 | LMNA 2290/4885MEN1 1608/4885KMT2A 678/4885 |
| US-10570161-B2 | Unique dual-action therapeutics | ACHE, PDE1A, PDE1C | LMNA 1380/4885MEN1 4345/4885KMT2A 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.