Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707311 | 0.84 | TSHR (0.47) | PSMB5ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL9667031 | 0.81 | CASP1 (0.48) | MRGPRX4PSMB5ALDH1A1KDM4EHPGD | |
| SCHEMBL6447325 | 0.78 | CASP1 (0.48) | MRGPRX4PSMB5ALDH1A1KDM4EHPGD | |
| SCHEMBL5491112 | 0.76 | PSMB5 (0.46) | MRGPRX4PSMB5ALDH1A1KDM4EHPGD | |
| SCHEMBL10595010 | 0.75 | HSD17B10 (0.54) | MRGPRX4ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL6708065 | 0.74 | CYP1A2 (0.51) | MRGPRX4ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL6447676 | 0.74 | TACR1 (0.48) | KDM4ETDP1CASP1KMT2AMEN1 | |
| SCHEMBL6446149 | 0.73 | CASP1 (0.47) | MRGPRX4PSMB5ALDH1A1KDM4EHPGD | |
| SCHEMBL6446143 | 0.73 | CASP1 (0.47) | MRGPRX4PSMB5ALDH1A1KDM4EHPGD | |
| SCHEMBL3051266 | 0.72 | ALDH1A1 (0.65) | MRGPRX4ALDH1A1KDM4EHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |