Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706995 | 0.85 | POLB (0.65) | POLBALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6706060 | 0.85 | POLB (0.61) | POLBALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL3606953 | 0.82 | SMN1; SMN2 (0.60) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4061312 | 0.78 | HTT (0.56) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL1662861 | 0.78 | NPC1 (0.58) | POLBMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL10246421 | 0.77 | MEN1 (0.59) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4931984 | 0.77 | MEN1 (0.62) | POLBMEN1KMT2APABPC1USP2 | |
| SCHEMBL3156502 | 0.75 | POLB (0.82) | POLBMEN1KMT2AALDH1A1RECQL | |
| SCHEMBL6591899 | 0.74 | LMNA (0.74) | POLBMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5258664 | 0.73 | MCHR1 (0.57) | ALDH1A1MAPTKDM4EHTTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235846-A1 | Administering substituted nicotinamides and nicotinamide analogs for therapy of disorder responsive to the induction of apoptosis in an animal; anti-cancer agents | CYTOVIA, INC. | 2004-11-25 | — | — | US | disclosed |
| US-6794397-B2 | ANTICARCINOGENIC AGENTS | CYTOVIA, INC. | 2004-09-21 | — | — | US | disclosed |
| EP-1257536-A1 | SUBSTITUTED NICOTINAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2002-11-20 | — | — | EP | disclosed |
| US-20020010185-A1 | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-01-24 | — | — | US | disclosed |
| WO-2001055115-A1 | SUBSTITUTED NICOTINAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010185-A1 | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP3, BAD, CASP12 | POLB 2535/4885MEN1 3202/4885KMT2A 3048/4885 |
| US-20040235846-A1 | Administering substituted nicotinamides and nicotinamide analogs for therapy of disorder responsive to the induction of apoptosis in an animal; anti-cancer agents | NAMPT, BAD, NNT | POLB 2857/4885MEN1 3283/4885KMT2A 3188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.