Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706060 | 0.88 | POLB (0.61) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6708262 | 0.85 | POLB (0.58) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL31665065 | 0.83 | KDM4E (0.62) | POLBSMN1; SMN2RAB9AALDH1A1HPGD | |
| SCHEMBL30354889 | 0.78 | SORT1 (0.53) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL31665319 | 0.78 | KMT2A (0.66) | SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3606953 | 0.78 | SMN1; SMN2 (0.60) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3156502 | 0.78 | POLB (0.82) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL15063035 | 0.77 | KMT2A (0.48) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL30354817 | 0.76 | MAPT (0.67) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6713220 | 0.75 | ALDH1A1 (0.61) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040235846-A1 | Administering substituted nicotinamides and nicotinamide analogs for therapy of disorder responsive to the induction of apoptosis in an animal; anti-cancer agents | CYTOVIA, INC. | 2004-11-25 | — | — | US | claimed |
| US-20020010185-A1 | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-01-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020010185-A1 | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP3, BAD, CASP12 | POLB 2535/4885SMN1; SMN2 2117/4885NPC1 698/4885 |
| US-20040235846-A1 | Administering substituted nicotinamides and nicotinamide analogs for therapy of disorder responsive to the induction of apoptosis in an animal; anti-cancer agents | NAMPT, BAD, NNT | POLB 2857/4885SMN1; SMN2 988/4885NPC1 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.