Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6709520 | 0.99 | DRD2 (0.43) | DRD2DRD4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6709629 | 0.87 | CHRNB4 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4PDCD1 | |
| SCHEMBL6711106 | 0.87 | CHRNB2 (0.44) | DRD2DRD4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6713062 | 0.87 | DRD2 (0.41) | DRD2DRD4CHRNB4CHRNA3ACHE | |
| Hydrochloric Acid SCHEMBL6709553 | 0.87 | CHRNB4 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4PDCD1 | |
| Hydrochloric Acid SCHEMBL6709633 | 0.86 | CHRNB2 (0.43) | DRD2DRD4CHRNB2CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL6708416 | 0.86 | DRD2 (0.41) | DRD2DRD4CHRNB4CHRNA3ACHE | |
| SCHEMBL6711003 | 0.85 | CHRNB4 (0.44) | DRD2DRD4CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6707480 | 0.85 | DRD4 (0.46) | DRD2DRD4CHRNA4POLBACHE | |
| Hydrochloric Acid SCHEMBL6708369 | 0.84 | CHRNB4 (0.43) | DRD2DRD4CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110788-A1 | Nicotinic acetylcholine receptor ligands | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | US | claimed |
| US-20040110788-A1 | Nicotinic acetylcholine receptor ligands | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110788-A1 | Nicotinic acetylcholine receptor ligands | CHRNA1, CHRNA2, CHRNA10 | DRD2 117/4885DRD4 443/4885CHRNB2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.