Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ARHGDIA | P52565 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6708369 | 0.99 | CHRNB4 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4TRPA1 | |
| SCHEMBL6709629 | 0.90 | CHRNB4 (0.53) | CHRNB4CHRNA3CHRNB2CHRNA4PDCD1 | |
| Hydrochloric Acid SCHEMBL6709553 | 0.89 | CHRNB4 (0.52) | CHRNB4CHRNA3CHRNB2CHRNA4PDCD1 | |
| SCHEMBL6711106 | 0.86 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB2CHRNA4DRD2 | |
| SCHEMBL6709552 | 0.86 | CHRNB4 (0.38) | CHRNB4CHRNA3DRD2DRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6709633 | 0.85 | CHRNB2 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4DRD2 | |
| SCHEMBL6708595 | 0.85 | DRD2 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4DRD2 | |
| Hydrochloric Acid SCHEMBL6711193 | 0.85 | CHRNB4 (0.37) | CHRNB4CHRNA3DRD2DRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6709520 | 0.84 | DRD2 (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4DRD2 | |
| SCHEMBL6709556 | 0.84 | DRD2 (0.37) | CHRNB4CHRNA3DRD2DRD4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110788-A1 | Nicotinic acetylcholine receptor ligands | MERCK PATENT GMBH (DE) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110788-A1 | Nicotinic acetylcholine receptor ligands | CHRNA1, CHRNA2, CHRNA10 | CHRNB4 19/4885CHRNA3 9/4885CHRNB2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.