Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD2 | O60906 | 2/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817482 | 0.80 | SMPD2 (0.43) | SMPD2KDM4EALDH1A1F2LMNA | |
| SCHEMBL9859576 | 0.78 | SMPD2 (0.43) | SMPD2GRIK1GRIK2KDM4EALDH1A1 | |
| SCHEMBL6028188 | 0.77 | SMPD2 (0.41) | SMPD2GRIK1GRIK2KDM4EALDH1A1 | |
| SCHEMBL27544275 | 0.76 | SMPD2 (0.40) | SMPD2GRIK1GRIK2KDM4EALDH1A1 | |
| SCHEMBL5254370 | 0.74 | RXRA (0.41) | SMPD2GRIK1GRIK2KDM4EALDH1A1 | |
| Alanine SCHEMBL1942247 | 0.73 | SMPD2 (0.51) | SMPD2GRIK1GRIK2KDM4EALDH1A1 | |
| SCHEMBL6907446 | 0.72 | CTNNB1 (0.59) | KDM4EALDH1A1TDP1MMEACE | |
| SCHEMBL16017641 | 0.72 | CTNNB1 (0.59) | KDM4EALDH1A1TDP1MMEACE | |
| SCHEMBL25846959 | 0.72 | CTNNB1 (0.59) | KDM4EALDH1A1TDP1MMEACE | |
| SCHEMBL12892302 | 0.72 | ALDH1A1 (0.49) | SMPD2GRIK1GRIK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392315-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002100410-A1 | METHODS OF TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-12-19 | — | — | WO | disclosed |