SCHEMBL6709883

SCHEMBL6709883

O=C(COc1ccc2ccccc2c1)Nc1cccc2cc(C(=O)Nc3ccc(Cl)cc3-c3noc(=O)[nH]3)[nH]c12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
LMNA P02545 3/20 0.43
MAPT P10636 3/20 0.43
CASP3 P42574 1/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HTT P42858 1/20 0.41
PRSS12 P56730 1/20 0.40
GALR3 O60755 1/20 0.40
STAT3 P40763 1/20 0.40
GRIK1 P39086 1/20 0.39
POLB P06746 3/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6708672 0.94 NPC1 (0.46) GAARXFP1LMNAMAPTPRSS12
SCHEMBL6707769 0.91 MEN1 (0.48) GAARXFP1MEN1KMT2ALMNA
SCHEMBL6921771 0.91 MAPT (0.40) GAARXFP1MEN1KMT2ALMNA
SCHEMBL6713903 0.89 GAA (0.43) GAARXFP1MEN1KMT2ALMNA
SCHEMBL6713838 0.88 GRIK1 (0.41) LMNAMAPTHTTGRIK1POLB
SCHEMBL6707625 0.88 GSK3A (0.41) MEN1KMT2ALMNAGRIK1POLB
SCHEMBL6710410 0.87 USP2 (0.43) LMNAMAPTGRIK1POLBSMN1; SMN2
SCHEMBL6707994 0.86 CETP (0.43) MAPTGRIK1POLBG6PD
SCHEMBL6712543 0.86 GRIK1 (0.43) RXFP1MEN1KMT2ALMNAMAPT
SCHEMBL6709877 0.86 GRIK1 (0.43) MEN1KMT2ALMNAMAPTGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 GAA 111/4885RXFP1 3836/4885MEN1 4100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.