SCHEMBL6710345

SCHEMBL6710345

O=C(Nc1ccc(Cl)cc1-c1noc(=O)[nH]1)c1noc2cc(OS(=O)(=O)c3ccccc3)ccc12

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 2/20 0.42
ENPP1 P22413 2/20 0.42
HIF1A Q16665 6/20 0.42
ALPL P05186 2/20 0.39
ALPI P09923 2/20 0.39
GRIK1 P39086 1/20 0.38
MAOB P27338 2/20 0.37
ENPP2 Q13822 1/20 0.36
TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6710206 0.91 MAOB (0.37) ENPP3ENPP1HIF1AALPLALPI
SCHEMBL6713524 0.88 ALPL (0.41) ENPP3ENPP1HIF1AALPLALPI
SCHEMBL6707640 0.88 HIF1A (0.40) HIF1AGRIK1
SCHEMBL6920279 0.87 ENPP3 (0.40) ENPP3ENPP1HIF1AALPLALPI
SCHEMBL6711834 0.85 HIF1A (0.46) HIF1AGRIK1TDP1
SCHEMBL6709014 0.85 HIF1A (0.48) HIF1AGRIK1MAOB
SCHEMBL6713299 0.85 HIF1A (0.43) HIF1AGRIK1MAOB
SCHEMBL6709033 0.84 HIF1A (0.49) HIF1AGRIK1
SCHEMBL6713562 0.83 HIF1A (0.41) HIF1AGRIK1
SCHEMBL6710367 0.83 HIF1A (0.47) HIF1AGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142981-A1 Antibacterial benzoic acid derivatives PHARMACIA & UPJOHN COMPANY 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142981-A1 Antibacterial benzoic acid derivatives GABRD, PHB1, GABBR1 ENPP3 3313/4885ENPP1 2398/4885HIF1A 296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.