Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320269 | 0.82 | TSHR (0.50) | MTNR1AMTNR1BKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL16817994 | 0.81 | CYP3A4 (0.39) | KMT2AMEN1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL14909477 | 0.79 | MAPK1 (0.36) | KMT2AMEN1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL1925718 | 0.78 | RAB9A (0.51) | MTNR1AMTNR1BKMT2ASMN1; SMN2PTGES | |
| SCHEMBL4600519 | 0.77 | MTNR1A (0.47) | MTNR1AMTNR1BKMT2AALDH1A1KDM4E | |
| SCHEMBL67323 | 0.76 | MTNR1A (0.44) | MTNR1AMTNR1BRIPK1KMT2AMEN1 | |
| SCHEMBL12541476 | 0.74 | ALDH1A1 (0.44) | KMT2AMEN1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL14200998 | 0.74 | MTNR1A (0.41) | MTNR1AMTNR1BRIPK1KMT2AMEN1 | |
| SCHEMBL67698 | 0.73 | POLB (0.41) | KMT2AMEN1SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL3452581 | 0.73 | ALDH1A1 (0.47) | MTNR1AMTNR1BKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814871-B1 | COMPOUNDS THAT MODULATE PPARY TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RES & DEV (FR) | 2011-03-02 | — | — | EP | disclosed |
| US-7863332-B2 | Biaromatic compound activators of PPARγ receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-01-04 | — | — | US | disclosed |