Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 7/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 7/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 7/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 7/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 7/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 7/20 | 0.48 |
| ▸ | MDH2 | P40926 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955456 | 0.84 | KDM4E (0.49) | HTTKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL6713044 | 0.84 | MDH2 (0.55) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL8913208 | 0.83 | HTT (0.51) | HTTKDM4EMDH2MEN1KMT2A | |
| SCHEMBL6712878 | 0.82 | CSNK2A2 (0.54) | HTTKDM4EPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL6717561 | 0.80 | MDH2 (0.54) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL3646574 | 0.80 | HTT (0.51) | HTTKDM4EMDH2MEN1KMT2A | |
| SCHEMBL4649270 | 0.80 | KDM4E (0.57) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL10478126 | 0.79 | KDM4E (0.60) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4650048 | 0.79 | KDM4E (0.50) | KDM4EPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL15956339 | 0.79 | GABRA1 (0.57) | HTTKDM4EMDH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453846-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003042228-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2003-05-22 | — | — | WO | disclosed |