Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDH2 | P40926 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.49 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6713044 | 0.96 | MDH2 (0.55) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4649270 | 0.87 | KDM4E (0.57) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL15956339 | 0.86 | GABRA1 (0.57) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL17338533 | 0.85 | ALDH1A1 (0.54) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4650661 | 0.84 | ALDH1A1 (0.60) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4650034 | 0.82 | KDM4E (0.49) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4650042 | 0.82 | ALDH1A1 (0.58) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4649431 | 0.81 | MDH2 (0.52) | MDH2ALDH1A1HPGDSMN1; SMN2GABRA1 | |
| SCHEMBL4650048 | 0.81 | KDM4E (0.50) | MDH2ALDH1A1HPGDSMN1; SMN2PRKAB2 | |
| SCHEMBL4649044 | 0.81 | PRKAB2 (0.46) | MDH2ALDH1A1HPGDSMN1; SMN2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453846-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003042228-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2003-05-22 | — | — | WO | disclosed |