Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | EGFR | P00533 | 1/20 | 0.70 |
| ▸ | FYN | P06241 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | APEX1 | P27695 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.70 |
| ▸ | MTOR | P42345 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819512 | 1.00 | ALDH1A1 (0.70) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL6340551 | 0.88 | GAA (0.70) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL6337564 | 0.88 | GAA (0.70) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL6339568 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL29658681 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL24534351 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL6339567 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL29658682 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| SCHEMBL7386597 | 0.87 | ALDH1A1 (0.60) | ALDH1A1CYP3A4GAATDP1BLM | |
| Hydrochloric Acid SCHEMBL30149960 | 0.87 | ALDH1A1 (0.59) | ALDH1A1CYP3A4GAATDP1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | claimed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | claimed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1992001667-A1 | RENAL-SELECTIVE PRODRUGS FOR CONTROL OF RENAL SYMPATHETIC NERVE ACTIVITY IN THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1992-02-06 | — | — | WO | claimed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | claimed |
| US-4740615-A | LOW PRESSURE TEMPERATURE GRADIENT CHROMATOGRAPHY | MERCK & CO., INC. (US) | 1988-04-26 | — | — | US | claimed |
| WO-2023178183-A1 | COMBINATORIAL ACTIVATION OF GABA(B) AND ALPHA-2 ADRENERGIC RECEPTORS FOR TREATMENT OF STRESS INDUCED DEPRESSION | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2023-09-21 | — | — | WO | disclosed |
| US-11052060-B2 | Compounds and methods for treating autoimmunity | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-07-06 | — | — | US | disclosed |
| US-20190262301-A1 | COMPOUNDS AND METHODS FOR TREATING AUTOIMMUNITY | IMMUNOMOLECULAR THERAPEUTICS, INC. | 2019-08-29 | — | — | US | disclosed |
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2004-05-27 | — | — | US | disclosed |
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | G.D. SEARLE & CO. | 2003-11-27 | — | — | US | disclosed |
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | disclosed |
| WO-1991001724-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. SEARLE & CO. (US) | 1991-02-21 | — | — | WO | disclosed |
| EP-0266117-A1 | Process for purified amino acids | MERCK & CO. INC. (US) | 1988-05-04 | — | — | EP | disclosed |
| US-4740615-A | LOW PRESSURE TEMPERATURE GRADIENT CHROMATOGRAPHY | MERCK & CO., INC. (US) | 1988-04-26 | — | — | US | disclosed |
| US-4393242-A | Process for preparing methylvanillyl ketone from isoeugenol | MERCK & CO., INC. (US) | 1983-07-12 | — | — | US | disclosed |
| US-4337360-A | EPOXIDATION OF PROTECTED ISOEUGENOL FOLLOWED BY ACID HYDROLYSIS | MERCK & CO., INC. (US) | 1982-06-29 | — | — | US | disclosed |
| US-4273943-A | OXIDATION OF ISOEUGENOL WITH ACID HYDROLYSIS | MERCK & CO., INC. (US) | 1981-06-16 | — | — | US | disclosed |
| US-4230893-A | 1,1-Di(4-hydroxy-3-methoxyphenyl)-2-alkoxypropane | MERCK & CO., INC. (US) | 1980-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220521-A1 | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension | GLS, APEH, GGH | ALDH1A1 100/4885CYP3A4 1387/4885GAA 171/4885 |
| US-20190262301-A1 | COMPOUNDS AND METHODS FOR TREATING AUTOIMMUNITY | HLA-DRB1, CD74, MICA | ALDH1A1 4242/4885CYP3A4 4783/4885GAA 78/4885 |
| US-11052060-B2 | Compounds and methods for treating autoimmunity | HLA-DRB1, CD74, MICA | ALDH1A1 4242/4885CYP3A4 4783/4885GAA 78/4885 |
| US-20040101523-A1 | Renal-selective prodrugs for control of renal smpathetic nerve activity in the treatment of hypertension | GLS, DBH, APEH | ALDH1A1 114/4885CYP3A4 2033/4885GAA 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.