Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714982 | 1.00 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL6926961 | 0.85 | KDM4E (0.43) | SMN1; SMN2KDM4EHDAC1HDAC2SIRT2 | |
| SCHEMBL6926964 | 0.85 | KDM4E (0.43) | SMN1; SMN2KDM4EHDAC1HDAC2SIRT2 | |
| SCHEMBL7789115 | 0.83 | SIRT2 (0.42) | NPC1HDAC1HDAC2CYP11B1CYP11B2 | |
| SCHEMBL7789120 | 0.83 | SIRT2 (0.42) | NPC1HDAC1HDAC2CYP11B1CYP11B2 | |
| SCHEMBL28361973 | 0.82 | NPC1 (0.51) | RAB9ANPC1SIRT2CA1CA2 | |
| SCHEMBL312750 | 0.81 | CYP11B1 (0.43) | RAB9ASMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL7684568 | 0.80 | CYP11B1 (0.40) | RAB9ASMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL7684566 | 0.80 | CYP11B1 (0.40) | RAB9ASMN1; SMN2LMNACYP11B1CYP11B2 | |
| SCHEMBL7082566 | 0.80 | CYP1B1 (0.53) | SMN1; SMN2KDM4ELMNAHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | GENENTECH, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| US-11530298-B2 | Poly(phosphoesters) for delivery of nucleic acids | TRANSLATE BIO, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| US-11530298-B2 | Poly(phosphoesters) for delivery of nucleic acids | TRANSLATE BIO, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| EP-4047039-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | Translate Bio, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |
| EP-3601259-B1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HOFFMANN LA ROCHE (CH) | 2022-02-23 | — | — | EP | disclosed |
| EP-3638716-B1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO INC (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-3638716-B1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO INC (US) | 2022-01-05 | — | — | EP | disclosed |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2021-06-03 | — | — | US | disclosed |
| US-20200277446-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO, INC. | 2020-09-03 | — | — | US | disclosed |
| US-20200277446-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | TRANSLATE BIO, INC. | 2020-09-03 | — | — | US | disclosed |
| EP-3601259-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | H. Hoffnabb-La Roche Ag (CH) | 2020-02-05 | — | — | EP | disclosed |
| US-20180282282-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | US | disclosed |
| WO-2018183964-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | GENENTECH, INC. (US) | 2018-10-04 | — | — | WO | disclosed |
| US-20040092524-A1 | Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same | PIERRE FABRE MEDICAMENT (FR) | 2004-05-13 | — | — | US | disclosed |
| US-20010047100-A1 | Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives | KJAERSGAARD HANS JOERGEN (DK) | 2001-11-29 | — | — | US | disclosed |
| WO-2001081317-A1 | CHIRAL IMIDAZOYL INTERMEDIATES FOR THE SYNTHESIS OF 2-(4-IMIDAZOYL)-CYCLOPROPYL DERIVATIVES | GLIATECH, INC. (US) | 2001-11-01 | — | — | WO | disclosed |
| US-4948796-A | TREATING CEREBO-VASCULARE DISEASES | TOYAMA CHEMICAL CO., LTD. (JP) | 1990-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277446-A1 | POLY(PHOSPHOESTERS) FOR DELIVERY OF NUCLEIC ACIDS | POLR2E, POLR2H, POLR1A | RAB9A 1700/4885NPC1 534/4885SMN1; SMN2 47/4885 |
| US-20040092524-A1 | Novel aminophenyl piperazine or aminophenyl piperidine derivatives inhibiting prenyl transferase proteins and method for preparing same | CBR3, CBR1, HCCS | RAB9A 345/4885NPC1 104/4885SMN1; SMN2 4744/4885 |
| US-11530298-B2 | Poly(phosphoesters) for delivery of nucleic acids | POLR2E, POLR2H, POLR1A | RAB9A 1700/4885NPC1 534/4885SMN1; SMN2 47/4885 |
| US-20180282282-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HIPK1, HPGDS, IP6K1 | RAB9A 2701/4885NPC1 931/4885SMN1; SMN2 3749/4885 |
| US-11566003-B2 | Isoquinolines as inhibitors of HPK1 | HIPK1, HIPK2, IP6K1 | RAB9A 2736/4885NPC1 1022/4885SMN1; SMN2 3545/4885 |
| US-20210163417-A1 | ISOQUINOLINES AS INHIBITORS OF HPK1 | HIPK1, HIPK2, IP6K1 | RAB9A 2736/4885NPC1 1022/4885SMN1; SMN2 3545/4885 |
| US-20010047100-A1 | Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives | HRH4, HRH2, HRH1 | RAB9A 2082/4885NPC1 3934/4885SMN1; SMN2 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.