Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | UBE2M | P61081 | 2/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464908 | 1.00 | RORC (0.44) | RORCBACE1PTGDR2MAPTNPC1 | |
| SCHEMBL5463410 | 0.90 | RORC (0.42) | RORCBACE1PTGDR2MAPTNPC1 | |
| SCHEMBL5746506 | 0.87 | RORC (0.42) | RORCBACE1NPC1RAB9AMGLL | |
| SCHEMBL6477484 | 0.85 | RORC (0.51) | RORCPTGDR2MAPTNPC1RAB9A | |
| SCHEMBL6477875 | 0.85 | RORC (0.46) | RORCPTGDR2MAPTNPC1RAB9A | |
| SCHEMBL6711562 | 0.83 | RORC (0.39) | RORCBACE1NPC1RAB9AMGLL | |
| SCHEMBL5744670 | 0.83 | RORC (0.39) | RORCBACE1NPC1RAB9AMGLL | |
| SCHEMBL5466676 | 0.83 | HSD11B1 (0.41) | RORCMAPTSMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL5461178 | 0.80 | ALDH1A1 (0.44) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6510132 | 0.78 | NPY2R (0.52) | BACE1PTGDR2MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385834-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2003027083-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2003-04-03 | — | — | WO | disclosed |