Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.65 |
| ▸ | DRD4 | P21917 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6715783 | 0.99 | SLC6A5 (0.64) | SLC6A5DRD4DRD2SIGMAR1HIF1A | |
| Fumaric Acid SCHEMBL6713953 | 0.95 | SLC6A5 (0.59) | SLC6A5DRD4DRD2SIGMAR1HIF1A | |
| SCHEMBL3731091 | 0.90 | DRD4 (0.68) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL6714432 | 0.89 | SLC6A5 (0.57) | SLC6A5DRD4SIGMAR1CHRM2CHRM1 | |
| SCHEMBL6714253 | 0.83 | DRD4 (0.55) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL20074561 | 0.82 | SIGMAR1 (0.60) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL6713957 | 0.82 | DRD4 (0.52) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL3731129 | 0.81 | MTTP (0.59) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL6714001 | 0.80 | DRD4 (0.57) | SLC6A5DRD4DRD2SIGMAR1CHRM2 | |
| SCHEMBL13351375 | 0.80 | MTTP (0.58) | DRD4DRD2SIGMAR1CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | claimed |
| EP-1335912-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2003-08-20 | — | — | EP | claimed |
| WO-2002042291-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-30 | — | — | WO | claimed |
| US-20090220421-A1 | METHOD FOR SCREENING MTP-INHIBITING COMPOUNDS | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
| US-20090220421-A1 | METHOD FOR SCREENING MTP-INHIBITING COMPOUNDS | MERCK PATENT GESELLSCHAFT (DE) | 2009-09-03 | — | — | US | disclosed |
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1335912-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GmbH (DE) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002042291-A1 | 4-(BIPHENYLCARBONYLAMINO)PIPERIDINE DERIVATIVES AS MTP INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | LIPC, CETP, MTTP | SLC6A5 811/4885DRD4 2894/4885DRD2 3455/4885 |
| US-20090220421-A1 | METHOD FOR SCREENING MTP-INHIBITING COMPOUNDS | MTTP, CETP, HDLBP | SLC6A5 1403/4885DRD4 4735/4885DRD2 4873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.