Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.60 |
| ▸ | DRD4 | P21917 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.54 |
| ▸ | UBE2M | P61081 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731091 | 0.92 | DRD4 (0.68) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL17675459 | 0.87 | SIGMAR1 (0.63) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL6715536 | 0.82 | SLC6A5 (0.65) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL7239441 | 0.82 | CCR3 (0.72) | SIGMAR1DRD4CCR3POLB | |
| Hydrochloric Acid SCHEMBL6715783 | 0.81 | SLC6A5 (0.64) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL3731129 | 0.81 | MTTP (0.59) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL13580486 | 0.80 | CCR3 (0.67) | SIGMAR1DRD4CCR3POLB | |
| SCHEMBL6715786 | 0.80 | CCR3 (0.62) | SIGMAR1DRD4CCR3SLC6A5CHRM4 | |
| Fumaric Acid SCHEMBL6713953 | 0.80 | SLC6A5 (0.59) | SIGMAR1DRD4DRD2CCR3SLC6A5 | |
| SCHEMBL6714001 | 0.79 | DRD4 (0.57) | SIGMAR1DRD4DRD2CCR3SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023526-B2 | Process for the preparation of lomitapide | HETERO RESEARCH FOUNDATION | 2018-07-17 | — | — | US | disclosed |
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | HETERO RESEARCH FOUNDATION (IN) | 2018-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105487-A1 | PROCESS FOR THE PREPARATION OF LOMITAPIDE | LIPA, LPAR4, CETP | SIGMAR1 1668/4885DRD4 2295/4885DRD2 2739/4885 |
| US-10023526-B2 | Process for the preparation of lomitapide | LIPA, LPAR4, CETP | SIGMAR1 1668/4885DRD4 2295/4885DRD2 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.