Sugi Predict

Sugi Predict / Compounds / SCHEMBL6715792

SCHEMBL6715792

SCHEMBL6715792

CCN(c1ccc(N(C(N)=O)c2ncc(C(C)C)s2)cc1)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.41
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ ALDH1A1 P00352 6/20 0.36
▸ CCNE1 P24864 6/20 0.35
▸ CDK2 P24941 6/20 0.35
▸ CDK5 Q00535 6/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ CCNT1 O60563 1/20 0.34
▸ CDK1 P06493 1/20 0.34
▸ CDK4 P11802 1/20 0.34
▸ CCNB1 P14635 1/20 0.34
▸ CCNA2 P20248 1/20 0.34
▸ CCND1 P24385 1/20 0.34
▸ CDK7 P50613 1/20 0.34
▸ CDK9 P50750 1/20 0.34
▸ CCNH P51946 1/20 0.34
▸ MNAT1 P51948 1/20 0.34
▸ CDK5R1 Q15078 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7257113 0.85 CDK2 (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL27570619 0.85 CDK2 (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL27572548 0.85 CDK2 (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL27551031 0.84 CDK2 (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL27574287 0.84 CCNE1 (0.37) MEN1KMT2AL3MBTL1ALDH1A1CCNE1
SCHEMBL6710898 0.84 MLYCD (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL28746582 0.83 F13A1 (0.40) MAPTMEN1KMT2AL3MBTL1ALDH1A1
SCHEMBL6711707 0.83 MLYCD (0.47) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2
SCHEMBL27574281 0.82 CDK2 (0.38) MAPTALDH1A1CCNE1CDK2CDK5
SCHEMBL27551074 0.82 CDK2 (0.38) ALDH1A1CCNE1CDK2CDK5SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124811-A1 2-UREIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.p.A. (IT) 2001-08-22 — — EP claimed
WO-2000026203-A1 2-UREIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 2000-05-11 — — WO claimed
US-20040157827-A1 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents PEVARELLO PAOLO (IT) 2004-08-12 — — US disclosed
US-20030187040-A1 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents PHARMACIA & UPJOHN SPA (IT) 2003-10-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030187040-A1 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents UCK2, ULK3, CDK2 MAPT 3745/4885MEN1 1294/4885KMT2A 2751/4885
US-20040157827-A1 2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents UCK2, ULK3, CDK2 MAPT 3745/4885MEN1 1294/4885KMT2A 2751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.