Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965800 | 0.88 | DRD2 (0.58) | AKR1C3HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL2857040 | 0.84 | AKR1C3 (0.64) | AKR1C3HTR7HTR1AMEN1KMT2A | |
| SCHEMBL17276412 | 0.84 | AKR1C3 (0.64) | AKR1C3HTR7HTR1AMEN1KMT2A | |
| SCHEMBL9565829 | 0.82 | AKR1C3 (0.62) | AKR1C3HTR7MEN1KMT2AGAA | |
| SCHEMBL3436755 | 0.81 | AKR1C3 (0.63) | AKR1C3MEN1KMT2AALDH1A1ADRB1 | |
| SCHEMBL28396664 | 0.80 | ADRB1 (0.71) | AKR1C3HTR1AALDH1A1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL6987606 | 0.80 | GRM5 (0.59) | AKR1C3HTR7MEN1KMT2AGAA | |
| SCHEMBL8274961 | 0.80 | ADAM10 (0.55) | AKR1C3HTR7MEN1KMT2AGAA | |
| SCHEMBL23064287 | 0.79 | GAA (0.67) | AKR1C3HTR2AMEN1KMT2AGAA | |
| SCHEMBL21987068 | 0.79 | MEN1 (0.72) | AKR1C3HTR1AHTR2AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146790-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-17 | — | — | EP | claimed |
| JP-2002535256-A | — | — | 2002-10-22 | — | — | JP | claimed |
| EP-1146790-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000042852-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |