Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NCF1 | P14598 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857040 | 0.84 | AKR1C3 (0.64) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17276412 | 0.84 | AKR1C3 (0.64) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL17996848 | 0.83 | ALDH1A1 (0.55) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6716320 | 0.82 | AKR1C3 (0.62) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5919531 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3436305 | 0.82 | ALDH1A1 (0.76) | AKR1C3ALDH1A1KMT2ATSHRNCF1 | |
| SCHEMBL3801245 | 0.82 | GAA (0.65) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL18701771 | 0.81 | ALDH1A1 (0.58) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL19962180 | 0.81 | SMN1; SMN2 (0.60) | AKR1C3ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12781876 | 0.81 | TSHR (0.61) | AKR1C3ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642209-B1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY Therapeutics LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| EP-3356345-B1 | HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3394056-B1 | COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE | SHY Therapeutics LLC (US) | 2021-04-14 | — | — | EP | disclosed |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2018-05-10 | — | — | US | disclosed |
| US-9926286-B2 | Vortioxetine intermediate and synthesis process thereof | SHANGHAI SYNCORES TECHNOLOGIES INC. LTD. (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9926286-B2 | Vortioxetine intermediate and synthesis process thereof | SHANGHAI SYNCORES TECHNOLOGIES INC. LTD. (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9926286-B2 | Vortioxetine intermediate and synthesis process thereof | SHANGHAI SYNCORES TECHNOLOGIES INC. LTD. (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9920021-B2 | Method of preparing vortioxetine | ZENTIVA K.S. (CZ) | 2018-03-20 | — | — | US | disclosed |
| US-20170204074-A1 | METHOD OF PREPARING VORTIOXETINE | ZENTIVA K.S. (CZ) | 2017-07-20 | — | — | US | disclosed |
| US-9708280-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2017-07-18 | — | — | US | disclosed |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | H. LUNDBECK A/S (DK) | 2016-05-19 | — | — | US | disclosed |
| US-9090575-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2015-07-28 | — | — | US | disclosed |
| US-20140163043-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2014-06-12 | — | — | US | disclosed |
| US-8476279-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2013-07-02 | — | — | US | disclosed |
| US-20120302553-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2012-11-29 | — | — | US | disclosed |
| US-8110567-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2012-02-07 | — | — | US | disclosed |
| US-20110009423-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2011-01-13 | — | — | US | disclosed |
| US-7683053-B2 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors | H. LUNDBECK A/S (DK) | 2010-03-23 | — | — | US | disclosed |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | H. LUNDBECK A/S (DK) | 2007-03-15 | — | — | US | disclosed |
| EP-0548798-A1 | Antiviral agent | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163043-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
| US-20180127389-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
| US-20120302553-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
| US-20070060574-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
| US-20160137620-A1 | Phenyl-Piperazine Derivatives As Serotonin Reuptake Inhibitors | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
| US-20170204074-A1 | METHOD OF PREPARING VORTIOXETINE | HTR5A, HTR1A, TPH1 | AKR1C3 2997/4885ALDH1A1 858/4885MEN1 3824/4885 |
| US-20110009423-A1 | PHENYL-PIPERAZINE DERIVATIVES AS SEROTONIN REUPTAKE INHIBITORS | TPH1, HTR5A, HTR2C | AKR1C3 2187/4885ALDH1A1 191/4885MEN1 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.