Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.62 |
| ▸ | HTR1D | P28221 | 7/20 | 0.62 |
| ▸ | HTR1B | P28222 | 7/20 | 0.62 |
| ▸ | HTR2C | P28335 | 5/20 | 0.62 |
| ▸ | HTR6 | P50406 | 4/20 | 0.62 |
| ▸ | HTR2A | P28223 | 3/20 | 0.62 |
| ▸ | HTR7 | P34969 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716633 | 0.93 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6787289 | 0.93 | HTR1A (0.62) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6718319 | 0.91 | MCHR1 (0.52) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6724432 | 0.91 | HTR1A (0.51) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6786870 | 0.91 | HTR1A (0.51) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6784669 | 0.90 | HTR1A (0.59) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6724448 | 0.90 | MAPT (0.58) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6720252 | 0.89 | HTR1A (0.57) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6716446 | 0.89 | HTR1A (0.55) | HTR1AHTR1DHTR1BHTR2CHTR6 | |
| SCHEMBL6787580 | 0.88 | HTR1A (0.49) | HTR1AHTR1DHTR1BHTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146790-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-17 | — | — | EP | claimed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | claimed |
| US-20040038982-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-02-26 | — | — | US | claimed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | claimed |
| JP-2002535256-A | — | — | 2002-10-22 | — | — | JP | claimed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1146790-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-10-24 | — | — | EP | claimed |
| WO-2000042852-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-27 | — | — | WO | claimed |
| EP-1146790-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-1313477-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20040038982-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-02-26 | — | — | US | disclosed |
| EP-1313477-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002005819-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |
| EP-1146790-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000042852-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040038982-A1 | Compounds and methods | CCR5, CXCR3, CCR2 | HTR1A 651/4885HTR1D 887/4885HTR1B 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.