Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672749 | 0.88 | TDP1 (0.31) | TDP1MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL5116803 | 0.74 | ROCK2 (0.50) | — | |
| SCHEMBL25244288 | 0.71 | MEN1 (0.33) | TDP1MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL9912664 | 0.68 | RAB9A (0.36) | HTTSMN1; SMN2 | |
| SCHEMBL7478096 | 0.67 | MEN1 (0.50) | TDP1MEN1KMT2AMAPT | |
| SCHEMBL16616069 | 0.66 | MEN1 (0.40) | TDP1MEN1KMT2AHTTL3MBTL1 | |
| SCHEMBL18905841 | 0.65 | GLA (0.41) | MEN1KMT2AMAPT | |
| SCHEMBL20115738 | 0.65 | CGAS (0.42) | KMT2AMAPT | |
| SCHEMBL17094558 | 0.65 | KDM6B (0.44) | HTTL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17094136 | 0.65 | ALDH1A1 (0.34) | TDP1MEN1KMT2AHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606033-A1 | SUBSTITUTED CYCLIC CARBOXAMIDE AND UREA DERIVATIVES AS LIGANDS OF THE VANILLOID RECEPTOR | Grünenthal GmbH (DE) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022487-A1 | SUBSTITUTED CYCLIC CARBOXAMIDE AND UREA DERIVATIVES AS LIGANDS OF THE VANILLOID RECEPTOR | Grünenthal GmbH (DE) | 2012-02-23 | — | — | WO | disclosed |