Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 5/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672169 | 0.81 | MAP4K1 (0.36) | PRKCZAXLCHEK1MAP4K1PRKCI | |
| SCHEMBL671779 | 0.80 | BRD4 (0.40) | ROCK1CDC42BPBCHEK1MAP4K1PRKCI | |
| SCHEMBL672171 | 0.75 | PRKCI (0.42) | CHEK1MAP4K1PRKCI | |
| SCHEMBL672170 | 0.74 | CCNT1 (0.37) | PRKCZAXLCHEK1MAP4K1PRKCI | |
| SCHEMBL672172 | 0.74 | PRKCI (0.41) | CHEK1MAP4K1PRKCIBRD4ATAD2 | |
| SCHEMBL671780 | 0.73 | PRKCI (0.40) | CHEK1PRKCIBRD4ATAD2 | |
| SCHEMBL671778 | 0.72 | JAK2 (0.41) | ROCK1CDC42BPBROCK2AXLCHEK1 | |
| SCHEMBL28188383 | 0.70 | HRH3 (0.49) | PRKCZMAP4K1PRKCIBRD4ATAD2 | |
| SCHEMBL28188382 | 0.70 | HRH3 (0.49) | PRKCZMAP4K1PRKCIBRD4ATAD2 | |
| SCHEMBL17961772 | 0.67 | KDM4E (0.46) | CHEK1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |