Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | NRAS | P01111 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PRKCI | P41743 | 4/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.32 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672169 | 0.84 | MAP4K1 (0.36) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL671778 | 0.82 | JAK2 (0.41) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL672172 | 0.79 | PRKCI (0.41) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL671780 | 0.74 | PRKCI (0.40) | NRASFLT3PRKCIRPS6KB1CHEK1 | |
| SCHEMBL671777 | 0.74 | ROCK1 (0.39) | MAP4K1PRKCIAXLCHEK1PRKCZ | |
| SCHEMBL672171 | 0.74 | PRKCI (0.42) | MAP4K1PRKCIRPS6KB1CHEK1PDPK1 | |
| SCHEMBL671779 | 0.70 | BRD4 (0.40) | MAP4K1PRKCIRPS6KB1CHEK1PDPK1 | |
| SCHEMBL28188382 | 0.67 | HRH3 (0.49) | MAP4K1PRKCIRPS6KB1PRKCZPRKD2 | |
| SCHEMBL28188383 | 0.67 | HRH3 (0.49) | MAP4K1PRKCIRPS6KB1PRKCZPRKD2 | |
| SCHEMBL1032977 | 0.64 | BRD4 (0.44) | CCNT1CCNKCCNE1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |