Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 11/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672171 | 0.82 | PRKCI (0.42) | CHEK1PRKCIUSP2ALDH1A1CYP1A2 | |
| SCHEMBL671777 | 0.80 | ROCK1 (0.39) | BRD4ATAD2ROCK1CDC42BPBCHEK1 | |
| SCHEMBL671780 | 0.78 | PRKCI (0.40) | BRD4ATAD2CHEK1PRKCIRPS6KB1 | |
| SCHEMBL671778 | 0.77 | JAK2 (0.41) | ROCK1CDC42BPBCHEK1PRKCIUSP2 | |
| SCHEMBL672169 | 0.74 | MAP4K1 (0.36) | CHEK1PRKCIUSP2ALDH1A1CYP1A2 | |
| SCHEMBL672172 | 0.74 | PRKCI (0.41) | BRD4ATAD2CHEK1PRKCIRPS6KB1 | |
| SCHEMBL672170 | 0.70 | CCNT1 (0.37) | CHEK1PRKCIUSP2ALDH1A1CYP1A2 | |
| SCHEMBL28188383 | 0.70 | HRH3 (0.49) | BRD4ATAD2PRKCIRPS6KB1MAP4K1 | |
| SCHEMBL28188382 | 0.70 | HRH3 (0.49) | BRD4ATAD2PRKCIRPS6KB1MAP4K1 | |
| SCHEMBL1032978 | 0.70 | BRD4 (0.44) | BRD4ATAD2CHEK1PRKCIUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |