Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NRAS | P01111 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.36 |
| ▸ | PRKCI | P41743 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL672170 | 0.82 | CCNT1 (0.37) | JAK2MAP4K1JAK1JAK3CYP1A2 | |
| SCHEMBL671780 | 0.77 | PRKCI (0.40) | NRASFLT3PRKCICHEK1IRAK4 | |
| SCHEMBL671779 | 0.77 | BRD4 (0.40) | MAP4K1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL672169 | 0.76 | MAP4K1 (0.36) | JAK2MAP4K1CYP1A2USP2ALDH1A1 | |
| SCHEMBL672172 | 0.73 | PRKCI (0.41) | MAP4K1NRASFLT3PRKCICCNT1 | |
| SCHEMBL671777 | 0.72 | ROCK1 (0.39) | MAP4K1ROCK1CDC42BPBPRKCICHEK1 | |
| SCHEMBL672171 | 0.72 | PRKCI (0.42) | MAP4K1CYP1A2USP2ALDH1A1HSD17B10 | |
| SCHEMBL28188382 | 0.69 | HRH3 (0.49) | MAP4K1PRKCIIRAK4 | |
| SCHEMBL28188383 | 0.69 | HRH3 (0.49) | MAP4K1PRKCIIRAK4 | |
| SCHEMBL1032977 | 0.66 | BRD4 (0.44) | CYP1A2USP2ALDH1A1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |