Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 10/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.37 |
| ▸ | NRAS | P01111 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671780 | 0.82 | PRKCI (0.40) | PRKCIBRD4ATAD2NRASFLT3 | |
| SCHEMBL672170 | 0.79 | CCNT1 (0.37) | PRKCIMAP4K1NRASFLT3RPS6KB1 | |
| SCHEMBL672171 | 0.78 | PRKCI (0.42) | PRKCIMAP4K1RPS6KB1PDPK1CHEK1 | |
| SCHEMBL672169 | 0.77 | MAP4K1 (0.36) | PRKCIMAP4K1NRASFLT3RPS6KB1 | |
| SCHEMBL671777 | 0.74 | ROCK1 (0.39) | PRKCIMAP4K1BRD4ATAD2CHEK1 | |
| SCHEMBL671779 | 0.74 | BRD4 (0.40) | PRKCIMAP4K1BRD4ATAD2RPS6KB1 | |
| SCHEMBL671778 | 0.73 | JAK2 (0.41) | PRKCIMAP4K1NRASFLT3CCNT1 | |
| SCHEMBL1032977 | 0.68 | BRD4 (0.44) | PRKCIBRD4ATAD2NRASFLT3 | |
| SCHEMBL1032978 | 0.68 | BRD4 (0.44) | PRKCIBRD4ATAD2NRASFLT3 | |
| SCHEMBL1033268 | 0.67 | BRD4 (0.44) | PRKCIBRD4ATAD2NRASFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606051-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | Hutchison Medipharma Limited (CN) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012022045-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |