Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | PAICS | P22234 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17641372 | 0.92 | L3MBTL1 (0.41) | L3MBTL1ARMAPTLMNAALDH1A1 | |
| SCHEMBL22366522 | 0.85 | LMNA (0.39) | L3MBTL1ARLMNAJAK2JAK1 | |
| SCHEMBL21069613 | 0.84 | JAK3 (0.37) | L3MBTL1ARJAK3KMT2AMEN1 | |
| SCHEMBL21071212 | 0.84 | JAK3 (0.37) | L3MBTL1ARJAK3KMT2AMEN1 | |
| SCHEMBL21879649 | 0.80 | ALDH1A1 (0.50) | L3MBTL1ARMAPTLMNAALDH1A1 | |
| SCHEMBL671403 | 0.75 | MAPT (0.39) | L3MBTL1PAICSMAPTLMNAJAK2 | |
| SCHEMBL4752985 | 0.73 | LMNA (0.38) | L3MBTL1MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL15894897 | 0.73 | ALDH1A1 (0.47) | L3MBTL1MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL2217595 | 0.73 | FFAR1 (0.52) | L3MBTL1PDK2 | |
| SCHEMBL16594174 | 0.72 | KIT (0.31) | L3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |