Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22366522 | 0.74 | LMNA (0.39) | LMNAKMT2ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL25969616 | 0.74 | CPB2 (0.38) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16293237 | 0.74 | LMNA (0.37) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL671963 | 0.73 | L3MBTL1 (0.39) | LMNAKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL1457114 | 0.72 | BPTF (0.39) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1457112 | 0.72 | BPTF (0.39) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3489062 | 0.71 | TBXAS1 (0.42) | LMNAKMT2ATHRBHTTFDPS | |
| SCHEMBL21879649 | 0.70 | ALDH1A1 (0.50) | LMNAKMT2ASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL10830752 | 0.69 | CA12 (0.40) | KMT2AALDH1A1MAPK1MEN1 | |
| SCHEMBL5521617 | 0.69 | TBXAS1 (0.49) | LMNATHRBHTTFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | disclosed |