Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719670 | 0.84 | IDO1 (0.41) | IDO1APPALDH1A1ABCB1TAAR1 | |
| SCHEMBL6720002 | 0.82 | IDO1 (0.39) | IDO1APPALDH1A1ABCB1TAAR1 | |
| SCHEMBL6717128 | 0.81 | SLC6A4 (0.42) | IDO1APPALDH1A1POLBABCB1 | |
| SCHEMBL6721585 | 0.81 | IDO1 (0.38) | IDO1APPALDH1A1ABCB1MAPT | |
| SCHEMBL6717622 | 0.80 | IDO1 (0.39) | IDO1APPALDH1A1ABCB1TAAR1 | |
| SCHEMBL6728445 | 0.78 | KDM4E (0.41) | IDO1ALDH1A1POLBPARP14PARP10 | |
| SCHEMBL14208844 | 0.71 | APLNR (0.42) | ALDH1A1GAAMAPT | |
| SCHEMBL6721777 | 0.69 | MAPT (0.51) | IDO1APPMAPTATML3MBTL1 | |
| SCHEMBL15580624 | 0.69 | ALDH1A1 (0.43) | ALDH1A1POLBABCB1MAPTL3MBTL1 | |
| SCHEMBL12936623 | 0.69 | IDO1 (0.60) | IDO1ALDH1A1ABCB1TAAR1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | WARNER-LAMBERT COMPANY LLC | 2004-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214832-A1 | Piperazine derivative renin inhibitors | REN, ACE, AGTR2 | IDO1 4197/4885APP 1385/4885ALDH1A1 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.