Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 5/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722561 | 0.88 | CTSS (0.45) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL6724180 | 0.84 | NPC1 (0.43) | CTSSPPARAKLK7KLK5AKT1 | |
| SCHEMBL6724196 | 0.83 | PPARA (0.43) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL6724130 | 0.80 | CTSS (0.47) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL6723598 | 0.78 | CTSS (0.46) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL8697793 | 0.76 | PPARA (0.65) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL31360771 | 0.76 | SMN1; SMN2 (0.49) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL7409262 | 0.76 | KLK7 (0.58) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL6719150 | 0.76 | CTSS (0.46) | CTSSPPARAPPARGKLK7KLK5 | |
| SCHEMBL6719123 | 0.75 | PPARA (0.47) | CTSSPPARAPPARGKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |