Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 5/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6719123 | 0.92 | PPARA (0.47) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL6723646 | 0.83 | CTSS (0.42) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL6723598 | 0.79 | CTSS (0.46) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL6719150 | 0.78 | CTSS (0.46) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL8697793 | 0.78 | PPARA (0.65) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL8699428 | 0.76 | CTSK (0.60) | PPARACTSSPPARGCTSKSMN1; SMN2 | |
| SCHEMBL31360771 | 0.75 | SMN1; SMN2 (0.49) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL6724130 | 0.75 | CTSS (0.47) | PPARACTSSPPARGKLK7KLK5 | |
| SCHEMBL6724186 | 0.73 | NPSR1 (0.48) | CTSSAKT1CTSKSMN1; SMN2CTSL | |
| SCHEMBL7409262 | 0.73 | KLK7 (0.58) | PPARACTSSPPARGKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |