Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726529 | 0.81 | ALDH1A1 (0.33) | ALDH1A1PDE5ANPC1KDM4E | |
| SCHEMBL6726785 | 0.72 | NPC1 (0.37) | ALDH1A1NPC1 | |
| SCHEMBL6719573 | 0.72 | GRIK1 (0.47) | ERCC5ALDH1A1PDE5ANPC1KDM4E | |
| SCHEMBL25344514 | 0.71 | ALDH1A1 (0.39) | ALDH1A1NPC1KDM4EHPGDHTT | |
| SCHEMBL6730106 | 0.71 | ALDH1A1 (0.39) | ALDH1A1NPC1 | |
| SCHEMBL25344264 | 0.71 | TYMP (0.48) | ALDH1A1HPGD | |
| SCHEMBL6722438 | 0.70 | ATM (0.38) | ALDH1A1NPC1KDM4EMEN1HPGD | |
| SCHEMBL6723898 | 0.68 | PNP (0.36) | ADORA2BALDH1A1NPC1MEN1HPGD | |
| SCHEMBL6719104 | 0.68 | NPC1 (0.53) | ALDH1A1NPC1KDM4EMEN1HPGD | |
| SCHEMBL6719388 | 0.68 | MAPT (0.45) | NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6673804-B1 | PREVENTING OR TREATING ARTHRITIS (PARTICULARLY OSTEOARTHRITIS) OR INHIBITING METASTASIS, INVASION OR GROWTH OF CANCER (PARTICULARLY BREAST CANCER) | SANKYO COMPANY, LIMITED (JP) | 2004-01-06 | — | — | US | disclosed |
| EP-1069110-A1 | SULFONAMIDE DERIVATIVES | Sankyo Company Limited (JP) | 2001-01-17 | — | — | EP | disclosed |